МЕТОДИ ЗА ОПРЕДЕЛУВАЊЕ НА АСПАРТАМ ВО ХРАНА METHODS FOR DETERMINATION OF ASPARTAME IN FOOD
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Aspartame (С14Н18N2O5) with IUPAC name methyl L- α - aspartyl - L - phenylalaninate is a low-calorie artificial sweetener that is used in food production, beverages and some vitamin supplements without sugar. Aspartame is ideal as a non-sugar sweetener, used in small concentrations in order to achieve the desired effect, but unfortunately there are lots of adverse effects on the human health. Despite the large number of studies that indicate the hazard of aspartame for the human health, it’s still used. For these reasons, it is particularly important to control the amount of aspartame in food products in order to achieve consumers health protection.
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Референци
1. Soffritti M., Padovani M., Tibaldi E., Falcioni L., Manservisi F. and Belpoggi F., (2014) The Carcinogenic Effects of Aspartame: The Urgent Need for Regulatory Re-Evaluation, AMERICAN JOURNAL OF INDUSTRIAL MEDICINE, 1-15.
2. Ager D. J., Pantaleone D. P., Henderson S. A., Katritzky A. R., Prakash I., Walters D. E. (1998). Commercial, Synthetic Non-nutritive Sweeteners. Angewandte Chemie International Edition 37 (13–24), 1802–1817.
3. European Food Safety Authority (EFSA)Scientific Opinion on the re-evaluation of aspartame (E 951) as a food additive, (2013), EFSA Panel on Food Additives and Nutrient Sources added to Food (ANS), , Parma, Italy, 1-263.
4. Nantachit K., Putiyanan S., Phoowiang P. (2008). Identification and determination methods of aspartame. Thai Pharmaceutical and Health Science Journal, 3(2), 214-218.
5. Wurtman R. J. (1983). Neurochemical Changes Following High-Dose Aspartame with Dietary Carbohydrates. New England Journal of Medicine, 389, 429-430
6. Wurtman R. (1985). Aspartase: Possible effect on seizure susceptibility. Lancet 2, 1060.
7. Wurtman R. J., Walker E. R. (1988). Dietary Phenylalanine and brain function. Birkhauser, Boston.
8. Walton R. (1986). Seizure and mania after high intake of aspartase. Psychosomat 27, 218-219.
9. Roberts H. J. (1988). Reactions attributed to aspartame containing products. Journal of Applied Nutrition 40, 85-94.
10. Barua J., Bal A. (1995). Emerging facts about aspartame. Journal of the diabetic association of
India, vol.35, No.4.
11. Woodrow C. M. (1984). Aspartame: Methanol and the public health. Journal of applied nutrition,
36 (1), 42-53.
2. Ager D. J., Pantaleone D. P., Henderson S. A., Katritzky A. R., Prakash I., Walters D. E. (1998). Commercial, Synthetic Non-nutritive Sweeteners. Angewandte Chemie International Edition 37 (13–24), 1802–1817.
3. European Food Safety Authority (EFSA)Scientific Opinion on the re-evaluation of aspartame (E 951) as a food additive, (2013), EFSA Panel on Food Additives and Nutrient Sources added to Food (ANS), , Parma, Italy, 1-263.
4. Nantachit K., Putiyanan S., Phoowiang P. (2008). Identification and determination methods of aspartame. Thai Pharmaceutical and Health Science Journal, 3(2), 214-218.
5. Wurtman R. J. (1983). Neurochemical Changes Following High-Dose Aspartame with Dietary Carbohydrates. New England Journal of Medicine, 389, 429-430
6. Wurtman R. (1985). Aspartase: Possible effect on seizure susceptibility. Lancet 2, 1060.
7. Wurtman R. J., Walker E. R. (1988). Dietary Phenylalanine and brain function. Birkhauser, Boston.
8. Walton R. (1986). Seizure and mania after high intake of aspartase. Psychosomat 27, 218-219.
9. Roberts H. J. (1988). Reactions attributed to aspartame containing products. Journal of Applied Nutrition 40, 85-94.
10. Barua J., Bal A. (1995). Emerging facts about aspartame. Journal of the diabetic association of
India, vol.35, No.4.
11. Woodrow C. M. (1984). Aspartame: Methanol and the public health. Journal of applied nutrition,
36 (1), 42-53.